Luna Musib Selected Research

enzastaurin

1/2016	Effects of enzastaurin and its metabolites on the QT interval in cancer patients.
6/2010	Enzastaurin plus temozolomide with radiation therapy in glioblastoma multiforme: a phase I study.
3/2010	Phase III study of enzastaurin compared with lomustine in the treatment of recurrent intracranial glioblastoma.
2/2010	A phase I/II trial of enzastaurin in patients with recurrent high-grade gliomas.
12/2009	Carboplatin and paclitaxel in combination with oral enzastaurin in advanced ovarian or primary peritoneal cancer: results from a safety lead-in study.
5/2009	A phase I trial of enzastaurin in patients with recurrent gliomas.
3/2008	Enzastaurin, an oral serine/threonine kinase inhibitor, as second- or third-line therapy of non-small-cell lung cancer.
1/2008	A phase I safety, tolerability, and pharmacokinetic study of enzastaurin combined with capecitabine in patients with advanced solid tumors.
8/2007	Phase I pharmacokinetic and pharmacodynamic study of the oral protein kinase C beta-inhibitor enzastaurin in combination with gemcitabine and cisplatin in patients with advanced cancer.
5/2007	Phase II study of enzastaurin, a protein kinase C beta inhibitor, in patients with relapsed or refractory diffuse large B-cell lymphoma.

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Luna Musib Research Topics

Disease

21	Neoplasms (Cancer) 01/2022 - 08/2005
4	Fatigue 01/2020 - 09/2006
3	Melanoma (Melanoma, Malignant) 01/2021 - 08/2014
3	Glioblastoma (Glioblastoma Multiforme) 06/2010 - 08/2005
2	Breast Neoplasms (Breast Cancer) 12/2020 - 05/2012
2	Stomatitis 01/2020 - 08/2014
2	Nausea 01/2020 - 08/2014
2	Exanthema (Rash) 01/2020 - 08/2014
2	Glioma (Gliomas) 02/2010 - 05/2009
2	Thrombocytopenia (Thrombopenia) 02/2010 - 05/2009
2	Carcinoma (Carcinomatosis) 12/2009 - 08/2005
1	Chronic Renal Insufficiency 11/2022
1	Toxic Optic Neuropathy 01/2022
1	Basal Cell Carcinoma (Rodent Ulcer) 01/2021
1	Hypersensitivity (Allergy) 01/2020
1	Vomiting 01/2020
1	Dehydration (Water Stress) 01/2020
1	Diarrhea 01/2020
1	Dysgeusia (Parageusia) 01/2020
1	Prostatic Neoplasms (Prostate Cancer) 01/2019
1	Obesity 01/2018
1	Overweight 01/2018
1	Arthralgia (Joint Pain) 08/2014
1	Myalgia 08/2014
1	Squamous Cell Carcinoma (Epidermoid Carcinoma) 08/2014
1	Gliosarcoma 06/2010
1	Thrombosis (Thrombus) 02/2010
1	Hemorrhage 02/2010
1	Ovarian Neoplasms (Ovarian Cancer) 12/2009
1	Epilepsy (Aura) 04/2009
1	Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung) 03/2008
1	Dizziness (Lightheadedness) 03/2008
1	Disease Progression 05/2007
1	Diffuse Large B-Cell Lymphoma (Lymphoma, Large Cell, Diffuse) 05/2007
1	Colonic Neoplasms (Colon Cancer) 08/2005

Drug/Important Bio-Agent (IBA)

12	enzastaurinIBA 01/2016 - 08/2005
8	cobimetinibIBA 01/2022 - 11/2013
6	ipatasertibIBA 01/2022 - 01/2017
5	Mitogen-Activated Protein Kinase Kinases (MEKs)IBA 01/2022 - 08/2014
5	Protein Kinase C betaIBA 06/2010 - 09/2006
4	VemurafenibIBA 01/2021 - 08/2014
3	Pharmaceutical PreparationsIBA 01/2020 - 03/2008
3	EnzymesIBA 08/2014 - 05/2009
2	Biomarkers (Surrogate Marker)IBA 11/2022 - 01/2021
2	Pemetrexed (MTA)FDA Link 05/2012 - 08/2009
2	Anticonvulsants (Antiepileptic Drugs)IBA 02/2010 - 05/2009
2	Paclitaxel (Taxol)FDA LinkGeneric 12/2009 - 08/2009
2	Protein Kinase CIBA 03/2008 - 08/2007
1	CreatinineIBA 11/2022
1	Cystatin CIBA 11/2022
1	SuspensionsIBA 01/2022
1	TabletsIBA 01/2022
1	Cytochrome P-450 CYP3AIBA 12/2021
1	HhAntag691IBA 01/2021
1	Phosphotransferases (Kinase)IBA 01/2021
1	Rosuvastatin Calcium (Crestor)FDA Link 12/2020
1	Proteins (Proteins, Gene)FDA Link 12/2020
1	Creatine Kinase (Creatine Phosphokinase)IBA 01/2020
1	2- (1H- indazol- 4- yl)- 6- (4- methanesulfonylpiperazin- 1- ylmethyl)- 4- morpholin- 4- ylthieno(3,2- d)pyrimidineIBA 01/2020
1	Lipase (Acid Lipase)FDA Link 01/2020
1	3- (4- (2- (2- chloro- 4- fluorophenyl)- 1- (1H- indazol- 5- yl)but- 1- en- 1- yl)phenyl)acrylic acidIBA 10/2018
1	Estrogen ReceptorsIBA 10/2018
1	atezolizumabIBA 01/2018
1	trametinibIBA 01/2018
1	dabrafenibIBA 01/2018
1	pembrolizumabIBA 01/2018
1	IpilimumabIBA 01/2018
1	NivolumabIBA 01/2018
1	Dacarbazine (DIC)FDA LinkGeneric 01/2018
1	Adenosine Triphosphate (ATP)IBA 01/2017
1	Cytotoxins (Cytolysins)IBA 03/2016
1	Therapeutic UsesIBA 03/2016
1	Cytochrome P-450 CYP3A InducersIBA 11/2015
1	Alkaline PhosphataseIBA 08/2014
1	Cyclophosphamide (Cytoxan)FDA LinkGeneric 05/2012
1	Temozolomide (Temodar)FDA LinkGeneric 06/2010
1	Lomustine (CCNU)FDA Link 03/2010
1	Alanine Transaminase (SGPT)IBA 02/2010
1	Carboplatin (JM8)FDA LinkGeneric 12/2009
1	Carbamazepine (Tegretol)FDA LinkGeneric 04/2009
1	Proto-Oncogene Proteins c-akt (Protein Kinase B)IBA 03/2008
1	Protein Serine-Threonine Kinases (Protein-Serine-Threonine Kinase)IBA 03/2008
1	Capecitabine (Xeloda)FDA Link 01/2008
1	Gemcitabine FDA Link 08/2007
1	Cisplatin (Platino)FDA LinkGeneric 08/2007
1	Phosphatidylinositol 3-Kinase (1 Phosphatidylinositol 3 Kinase)IBA 08/2007
1	Glycogen Synthase Kinase 3 betaIBA 08/2005
1	Protein Kinases (Protein Kinase)IBA 08/2005

Therapy/Procedure

7	Therapeutics 01/2020 - 03/2008
2	Drug Therapy (Chemotherapy) 01/2018 - 12/2009
1	Castration 01/2019
1	Immunotherapy 01/2018
1	Radiotherapy 06/2010